United had a chance to equalize from another Southampton mistake at the back, as a poor pass from McCarthy put Greenwood through on goal again.

Once again, United would be made to pay for their profligacy. Down the other end Fred could not keep up with the run of Moussa Djenepo and committed a foul just outside of the box.

De Gea managed to get a palm to the ball, but he careened into the upright in his attempt to make the save.

Not only were United now two goals down, but their goalkeeper was now visibly struggling. Edinson Cavani also replaced Greenwood after the break, as Solskjaer looked to his bench for answers.

Jan Bednarek and Ward-Prowse had beaten the Spaniard in the first half, but Bruno Fernandes struck in the second half before an Edinson Cavani double sealed all three points for the visitors.

Read the full story here. Cavani came on at half-time with United down at Southampton and inspired them to a victory, assisting Bruno Fernandes' strike before netting twice - the winner coming in added time.

The year-old joined United on deadline day on October 5 and only made his first start in the midweek Champions League win over Istanbul Basaksehir, but is now pushing to start against former club Paris Saint-Germain on Wednesday.

I was surprised he didn't have his boots ready when the second-half started! Read more from Solskjaer on Cavani here. Dominic Booth has the post-match verdict for you on the Manchester is Red podcast below.

Also available on Apple Podcasts and Spotify. He knows what he wants to eat, how much he wants to recover - everything! It was top movement and his timing is fantastic.

Dean Henderson played well though. He wants to organise the team. He had a couple of tidy saves to make. He was safe with his hands. After the first half, we played well again.

At the end I was so proud at because we did so well. Hopefully, we see the return of the striker for Brighton but he should be back by the Sheffield match at the latest.

His work on and off the ball help create chances for himself and his teammates and I think we will be able to score more when he is out there.

I also believe Walcott will slide over to the left and still start for the club when Ings returns and Djenepo will be a weapon to bring off the bench.

The energetic defensive discipline of McTominay might be the safer call, but Solskjaer confirmed that the Scottish midfielder did not train on Friday.

I think the two of them [Edinson Cavani and Donny van de Beek] are getting used to how we want them to play. Of course, Donny can play in different positions.

Edinson is a good old-fashioned No. Victor Lindelöf, who has struggled with a bad back for weeks, left the match at halftime and Aaron Wan-Bissaka soon followed with an ankle injury.

With Phil Jones and Luke Shaw already sidelined for the foreseeable future, the defensive injuries are really starting to pile up.

The only other United player to achieve that feat was Solskjaer, who famously scored four off the bench against Nottingham Forest in United won the treble that season and, though the prospects of them doing so this campaign appear slim, Cavani maintaining that kind of form would be hugely important for a team whose young strikers lacked cutting edge on Sunday.

Southampton looked shaky at the back throughout and Walker-Peters was a key part of that. He lost possession 23 times, more than any other Saints player.

His opposite full-back, Ryan Bertrand 20 , was second. What a stop from McCarthy. Southampton doing more pressing here. Dean Henderson replaces him.

Edinson Cavani replaces the ineffective Mason Greenwood. El Matador is delayed in coming on as he changes his boots and has to take off a bracelet which Solskjaer takes off him.

Southampton worked hard but Manchester United had plenty of chances, as Greenwood and Bruno Fernandes twice went close. Little risky from Djenepo.

Romeu has just got the ball off Bruno Fernandes. Saints are hunting in packs. Southampton lead Saints in dreamland, as De Gea is hurt, but gets up.

Moments later he stops Djenepo from making it From that free kick, Southampton win a corner as Lindelof clears the danger.

Ward-Prowse whips in a superb corner that Jan Bednarek flicks home at the near post. Southampton lead.